Immunomodulative effects of aflatoxins and selenium on human natural killer cells

Authors
Methenitou, G Maravelias, C Athanaselis, S Dona, A Koutselinis, A
Citation
G. Methenitou et al., Immunomodulative effects of aflatoxins and selenium on human natural killer cells, VET HUM TOX, 43(4), 2001, pp. 232-234
Citations number
32
Categorie Soggetti
Veterinary Medicine/Animal Health
Journal title
VETERINARY AND HUMAN TOXICOLOGY
ISSN journal
01456296 → ACNP
Volume
43
Issue
4
Year of publication
2001
Pages
232 - 234
Database
ISI
SICI code
0145-6296(200108)43:4<232:IEOAAS>2.0.ZU;2-H
Abstract
The possible immunomodulative effects of anatoxin B-1 and selenium (as sodi um selenite) at concentrations lower than 5.10(-11) M or 0.05ppb and 10(-5) M, respectively on natural killer (NK) cells From healthy volunteers were evaluated by a Cr-51 release natural killer assay. Anatoxin B-1 and seleniu m separately had an immunosuppressive effect on NK cell activity. When they were studied in combination, they caused a statistically significant incre ase of the cytotoxic activity of NK cells in the presence of the lowest con centrations of anatoxin B-1 (0.005ppb) and of sodium selenite (10(-8) M).