Early control of HIV replication in primary HIV-1 infection treated with antiretroviral drugs and pegylated IFN alpha: results from the Primoferon A (ANRS 086) Study

IFN alpha has both antiviral and immunostimulating properties. The ANRS086 Primoferon A Study evaluated, in 12 patients with primary HIV infection the tolerance and efficacy of an early and transient administration of pegylat ed IFN alpha, in addition to highly active antiretroviral therapy. Toleranc e was good, and this regimen allowed the early control of HIV replication a nd rapid decay of the viral reservoir. These results support the initiation of comparative studies with pegylated IFN alpha in primary HIV infection.