INHIBITION OF CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES FROM BOVINE AORTA BY PAPAVERINE ANALOGS - A MULTIVARIATE APPROACH

In order to access relationships between the chemical structure of pap averine and 28 isoquinolic analogues and their enzymatic activity towa rd 3 types of cyclic phosphodiesterases (cAMP-PDE, cGMP-PDE, calmoduli n-PDE), we used mathematical methods of multidimensional data reductio n. Correspondence factorial analysis with simple graphical representat ion allowed us to define the relative specificity of the 29 molecules for the 3 enzymatic targets. Following these results, it is possible t o consider a pharmacomodulation of the structures studied.