Carboxymethyl-beta-cyclodextrin for chiral separation of basic drugs by capillary electrophoresis

Authors
Wang, W Lu, JD Fu, XY Chen, YZ
Citation
W. Wang et al., Carboxymethyl-beta-cyclodextrin for chiral separation of basic drugs by capillary electrophoresis, ANAL LETTER, 34(4), 2001, pp. 569-578
Citations number
15
Categorie Soggetti
Chemistry & Analysis","Spectroscopy /Instrumentation/Analytical Sciences
Journal title
ANALYTICAL LETTERS
ISSN journal
00032719 → ACNP
Volume
34
Issue
4
Year of publication
2001
Pages
569 - 578
Database
ISI
SICI code
0003-2719(2001)34:4<569:CFCSOB>2.0.ZU;2-Q
Abstract
Four basic drugs were separated by capillary electrophoresis(CE) using cycl odextrins(CDs) including beta -CD, hydroxypropyl-beta -CD(HP-beta -CD), hep takis-2, 6-di-O-methyl-beta -CD (CM-beta -CD) and carboxymethyl-beta -CD (C M-beta -CD) as chiral selectors. The effects of CM-beta -CD concentration, pH of buffer solution, applied voltage and operation temperature were inves tigated. Under the conditions of 100 mmol/L H3PO4-triethanolamine buffer at pH 3.1 containing various amounts of CM-beta -CD, baseline separation of t he enantiomers of salbutamol, norephedrine, ofloxacin and atenolol could be achieved.