SYNTHESIS AND PSYCHOTROPE EVALUATION OF NEW 3-UREIDOPROPAN-2-OLS USING THE SKIN-CONDUCTANCE REACTION (SCR)-HABITUATION TEST

The syntheses of 1-substituted 3-ureidopropan-2-ols 2 and 3-acetyl-5-( 1-phenyl-4-piperazinyl)methy 5 from the corresponding 2-amino-2 oxazol ines 1 are described. Some of these compounds have been investigated f or psychotropic activity in mice using the skin conductance reaction ( SCR)-habituation test. All the compounds produced a delay in habituati on. The standard delaying dose (SDD 150) that delays SCR extinction un til 150 100ths of an hour (+50% control time) was compared with that o f the reference drug fenozolone for all the compounds.