Schizencephaly rarely presents in the neonatal period. We present the case
of a baby girl born with growth retardation and microcephaly who developed
seizures on the 3rd day of life. There was no clinical or laboratory eviden
ce of a congenital viral infection but brain imaging revealed widespread ca
lcification and bilateral schizencephaly clefts. By the age of 11 months, s
he had developed gross psychomotor retardation.