Mutation in the DNA gyrase A gene of Escherichia coli that expands the quinolone resistance-determining region

Authors
Friedman, SM Lu, T Drlica, K
Citation
Sm. Friedman et al., Mutation in the DNA gyrase A gene of Escherichia coli that expands the quinolone resistance-determining region, ANTIM AG CH, 45(8), 2001, pp. 2378-2380
Citations number
22
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
45
Issue
8
Year of publication
2001
Pages
2378 - 2380
Database
ISI
SICI code
0066-4804(200108)45:8<2378:MITDGA>2.0.ZU;2-9
Abstract
In three Escherichia coli mutants, a change (Ala-51 to Val) in the gyrase A protein outside the standard quinolone resistance-determining region (QRDR ) lowered the level of quinolone susceptibility more than changes at amino acids 67, 82, 84, and 106 did. Revision of the QRDR to include amino acid 5 1 is indicated.