In vitro activities of ABT-773, a new ketolide, against aerobic and anaerobic pathogens isolated from antral sinus puncture specimens from patients with sinusitis

The comparative in vitro activities of ABT-773 against 207 aerobic and 162 anaerobic antral sinus puncture isolates showed that erythromycin-resistant pneumococcal strains were susceptible to ABT-773 (less than or equal to0.1 25 mug/ml); the MIC at which 90% of the isolates tested were inhibited for Haemophilus influenzae and other Haemophilus spp. was 4 mug/ml; and all Mor axella spp. and beta-lactamase-producing Prevotella species strains were in hibited by less than or equal to0.125 mug/ml. Among the anaerobes tested, o nly fusobacteria (45%) required greater than or equal to4 mug of ABT-773/ml for inhibition. ABT-773 may offer a therapeutic alternative for sinus infe ctions.