Influence of liposomal amphotericin B on CD8 T-cell function

Authors
Kretschmar, M Geginat, G Bertsch, T Walter, S Hof, H Nichterlein, T
Citation
M. Kretschmar et al., Influence of liposomal amphotericin B on CD8 T-cell function, ANTIM AG CH, 45(8), 2001, pp. 2383-2385
Citations number
15
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
45
Issue
8
Year of publication
2001
Pages
2383 - 2385
Database
ISI
SICI code
0066-4804(200108)45:8<2383:IOLABO>2.0.ZU;2-E
Abstract
Liposomal amphotericin B was immunosuppressive on target cell lysis in vitr o and on protection mediated by cytotoxic CD8 T cells in murine listeriosis . When dosages usually used for therapy in humans were compared, the immuno suppressive effect of 5 mg of liposomal amphotericin B/kg of body weight/da y was similar to that of standard amphotericin B at 1 mg/kg/day, but a dosa ge of liposomal amphotericin B of 1 mg/kg/day was not suppressive in vivo.