B cells, BAFF/zTNF4, TACl, and systemic lupus erythematosus

Citation
T. Dorner et C. Putterman, B cells, BAFF/zTNF4, TACl, and systemic lupus erythematosus, ARTHRITIS R, 3(4), 2001, pp. 197-199
Citations number
26
Categorie Soggetti
Rheumatology
Journal title
ARTHRITIS RESEARCH
ISSN journal
14659913 → ACNP
Volume
3
Issue
4
Year of publication
2001
Pages
197 - 199
Database
ISI
SICI code
1465-9913(2001)3:4<197:BCBTAS>2.0.ZU;2-#
Abstract
B cells and B-cell/T-cell collaborations are instrumental in the pathophysi ology of systemic lupus erythematosus (SLE). This commentary highlights in particular the newly discovered role of B-cell-activating factor (BAFF; als o known as TALL-1, THANK, BlyS, and zTNF4) as a positive regulator of B-cel l functions, such as B-cell activation and differentiation. Two members of the tumor necrosis factor(TNF)-receptor superfamily were recently identifie d as receptors for BAFF on B cells. The interaction between BAFF and its re ceptors may be important in the pathogenesis of lupus. Advances in our unde rstanding of abnormalities in immune regulation in lupus might provide the opportunity to improve our current therapeutic approaches to this disorder.