Tcf-3 expression and beta-catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour)

Authors
Tejpar, S Li, C Yu, C Poon, R Denys, H Sciot, R Van Cutsem, E Cassiman, JJ Alman, BA
Citation
S. Tejpar et al., Tcf-3 expression and beta-catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour), BR J CANC, 85(1), 2001, pp. 98-101
Citations number
20
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
BRITISH JOURNAL OF CANCER
ISSN journal
00070920 → ACNP
Volume
85
Issue
1
Year of publication
2001
Pages
98 - 101
Database
ISI
SICI code
0007-0920(20010706)85:1<98:TEABMT>2.0.ZU;2-J
Abstract
Aggressive fibromatosis harbours mutations resulting in beta -catenin prote in stabilization. Primary cell cultures demonstrate constitutive tcf activa tion in aggressive fibromatosis. Expression and co-immunoprecipitation stud ies suggest that beta -catenin binds and activates tcf-3 in this tumour. Th is is the first demonstration of tcf-3 activation by beta -catenin stabiliz ation in a human neoplastic process. (C) 2001 Cancer Research Campaign http ://www.bjcancer.com.