Trisomy 16 as the sole anomaly in hematological malignancies: three new cases and a short review

Authors
Guillaume, B Ameye, G Dierlamm, J Verhoef, G Duhem, C Ferrant, A Hagemeijer, A Verellen-Dumoulin, C Michaux, L
Citation
B. Guillaume et al., Trisomy 16 as the sole anomaly in hematological malignancies: three new cases and a short review, CANC GENET, 128(2), 2001, pp. 168-171
Citations number
7
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER GENETICS AND CYTOGENETICS
ISSN journal
01654608 → ACNP
Volume
128
Issue
2
Year of publication
2001
Pages
168 - 171
Database
ISI
SICI code
0165-4608(20010715)128:2<168:T1ATSA>2.0.ZU;2-3
Abstract
We report on three cases, two with myelodysplastic syndrome (MDS) and one w ith acute lymphoblastic leukemia (ALL). displaying trisomy 16 as the sole c ytogenetic anomaly. In none of these casts was a concomitant inv(lb)(p13q22 ) detected by fluorescence in situ hybridization (FISH) or revere transcrip tion polymerase chain reaction (RT-PCR). Summarizing the: literature, only six other cases cytogenctically characterized by an isolated trisomy 16 hav e been reported in hemato logical malignancies. These patients had tither M DS. acute myeloblastic leukemia (AML). my elofibrosis. or ALL. All but one: ol these eases were aged less than 50. (C) 2001 Elsevier Science Inc. All rights reserved.