Platelet H-3 ketanserin binding was studied in 33 patients of migraine and
30 healthy controls. The binding characteristics: equilibrium dissociation
constant (Kd) and maximal number of binding sites (Bmax) determined by Scat
chard analysis revealed a significant decrease in Kd and no change in Bmax
in migraine cases. No correlation was observed between the Kd and Bmax with
the clinical features of migraine. The findings of the present study show
that there is a decreased affinity of platelet 5-HT2 receptors in migraine.