Efficacy and safety of metamizol vs. acetylsalicylic acid in patients withmoderate episodic tension-type headache: a randomized, double-blind, placebo- and active-controlled, multicentre study

We assessed the efficacy and safety of oral single doses of 0.5 and 1 g met amizol vs. 1 g acetylsalicylic acid (ASA) in 417 patients with moderate epi sodic tension-type headache included in a randomized, double-blind, placebo - and active-controlled, parallel, multicentre trial. Eligibility criteria included 18-65 years of age, history of at least two episodes of tension-ty pe headache per month in the 3 months prior to enrolment, and successful pr evious pain relief with a non-opioid analgesic. Treatment arms were metamiz ol 0.5 g (n = 102), metamizol 1 g (n = 108), ASA 1 g (n = 102) and placebo (n=105). The analgesic efficacy of: 0.5 and 1 g metamizol vs. placebo was h ighly statistically significant (alpha: 0.025; one-sided) for sum of pain i ntensity differences, maximum pain intensity difference, number of patients with at least 50% pain reduction, time to 50% pain reduction, maximum pain relief and total pain relief. A trend towards an earlier onset of a more p rofound pain relief of 0.5 and 1 g metamizol over 1 g ASA was noticed. All medications including placebo were almost equally safe and well tolerated.