The practical synthesis of a uterine relaxant, bis(2-{[(2S)-2-({(2R)-2-hydroxy-2-[4-hydroxy-3-(2-hydroxyethyl)-phenyl]ethyl}amino)-1,2,3,4-tetrahydronaphthalen-7-yl]oxy}-N,N-dimethylacetamide) sulfate (KUR-1246)

The synthetic route for a uterine relaxant, bis(2-{[(2S)-2-({(2R)-2-hydroxy -2-[4-hydroxy-3-(2-hydroxyethyl)phenyl]ethyl}amino)-1,2,3,4-tetrahydronapht halen-7-yl]oxy}N,N-dimethylacetamide) sulfate (KUR-1246), was established b y the coupling of optically active components, the bromohydrin 14 and the a mine 24. We now describe the practical synthesis of these two optically act ive components. Bromohydrin 14 was obtained by the asymmetric borane reduct ion of the prochiral phenacyl bromide 13 using a catalyst prepared from alu minum triethoxide and a chiral amino alcohol. The other optically active co mponent 24 was prepared from (S)-AMT.