Cholestane glycosides from the bulbs of Galtonia candicans and their cytotoxicity

Authors
Kuroda, M Mimaki, Y Yokosuka, A Sashida, Y
Citation
M. Kuroda et al., Cholestane glycosides from the bulbs of Galtonia candicans and their cytotoxicity, CHEM PHARM, 49(8), 2001, pp. 1042-1046
Citations number
11
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
00092363 → ACNP
Volume
49
Issue
8
Year of publication
2001
Pages
1042 - 1046
Database
ISI
SICI code
0009-2363(200108)49:8<1042:CGFTBO>2.0.ZU;2-T
Abstract
Further search for cytotoxic compounds contained in the bulbs of Galtonia c andicans (Liliaceac) led to the isolation of four potent cytotoxic cholesta ne glycosides (1-4) based upon 3 beta ,16 beta ,17 alpha -trihydroxycholest -5-en-22-one, three of which (2-4) have not been reported previously. A new cholestane bisdesmoside (5) and a now rearranged cholestane glycoside (6) were also isolated. The structural assignment of the new constituents as ca rried out by spectroscopic analysis and a few chemical transformations.