[Ru(eta(6)-p-cymene)Cl-2(pta)] (pta=1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane): a water soluble compound that exhibits pH dependent DNA binding providing selectivity for diseased cells

Authors
Allardyce, CS Dyson, PJ Ellis, DJ Heath, SL
Citation
Cs. Allardyce et al., [Ru(eta(6)-p-cymene)Cl-2(pta)] (pta=1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane): a water soluble compound that exhibits pH dependent DNA binding providing selectivity for diseased cells, CHEM COMMUN, (15), 2001, pp. 1396-1397
Citations number
12
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
15
Year of publication
2001
Pages
1396 - 1397
Database
ISI
SICI code
1359-7345(2001):15<1396:[(>2.0.ZU;2-Y
Abstract
The water soluble complex [Ru(eta (6)-p-cymene)Cl-2(pta)] (pta = 1,3,5-tria za-7-phosphatricyclo[3.3.1.1]decane), exhibits pH dependent DNA damage; the pH at which damage is greatest correlates well to the pH environment of ca ncer cells.