Synthesis of 4-hydroxy-3-quinolinecarboxylic acid derivatives by a condensation/cyclization sequence between o-isocyanobenzoates and magnesium enolates

Authors
Kobayashi, K Nakashima, T Mano, M Morikawa, O Konishi, H
Citation
K. Kobayashi et al., Synthesis of 4-hydroxy-3-quinolinecarboxylic acid derivatives by a condensation/cyclization sequence between o-isocyanobenzoates and magnesium enolates, CHEM LETT, (7), 2001, pp. 602-603
Citations number
24
Categorie Soggetti
Chemistry
Journal title
CHEMISTRY LETTERS
ISSN journal
03667022 → ACNP
Issue
7
Year of publication
2001
Pages
602 - 603
Database
ISI
SICI code
0366-7022(20010705):7<602:SO4ADB>2.0.ZU;2-Q
Abstract
Addition of magnesium ester and amide enolates, generated using an excess a mount of a magnesium amide (from diisopropylamine and ethylmagnesium bromid e), to o-isocyanobenzoates affords 4-hydroxy-3-quinolinecarboxylic esters a nd amides by a tandem Claisen-type condensation/cyclization sequence.