Synthesis and DNA binding property of a novel peptide nucleic acid that contains cis-4-adeninyl-L-prolinol unit

Authors
Shigeyasu, M Kuwahara, M Sisido, M Ishikawa, T
Citation
M. Shigeyasu et al., Synthesis and DNA binding property of a novel peptide nucleic acid that contains cis-4-adeninyl-L-prolinol unit, CHEM LETT, (7), 2001, pp. 634-635
Citations number
9
Categorie Soggetti
Chemistry
Journal title
CHEMISTRY LETTERS
ISSN journal
03667022 → ACNP
Issue
7
Year of publication
2001
Pages
634 - 635
Database
ISI
SICI code
0366-7022(20010705):7<634:SADBPO>2.0.ZU;2-V
Abstract
A novel oxy-peptide nucleic acid that contains a cis-4-adeninyl-L-prolinol unit in the main chain (PPNA) was synthesized. The peptide nucleic acid wit h nine adenine units [PPNA(A,)I hybridized with the complementary DNA (Tg). The hybrid showed a very sharp melting curve with T-m= 34 degreesC.