Transmural distribution of three-dimensional systolic strains in stunned myocardium

Background - Regional function in stunned myocardium is usually thought to be more depressed in the endocardium than the epicardium. This has been att ributed to the greater loss of blood flow at the endocardium during ischemi a. Methods and Results We measured transmural distributions of 3D systolic str ains relative to local myofiber axes in open-chest anesthetized dogs before 15 minutes of left anterior descending coronary artery occlusion and durin g 2 hours of reperfusion. During ischemia, regional myocardial blood flow w as reduced 84% at the endocardium and 32% at the epicardium (P <0.005, n=7) , but chan,aes in end-systolic fiber length from baseline were transmurally uniform. Relative to baseline, radial segments in stunned tissue were sign ificantly thinner at the endocardium than the epicardium at end systole (24 +/-5% versus 16 +/-3%; P <0.05, n=8), consistent with previous reports. Un like radial and cross-fiber segments, however, the increase of end-systolic fiber lengths in stunned myocardium had no significant transmural gradient (23 +/-8% epicardium versus 21 +/-4% endocardium). We also observed signif icant 3D diastolic dysfunction in the ischemic-reperfused region transmural ly. Conclusions - Myocardial ischemia/reperfusion in the dog results in a signi ficant transmural gradient of dysfunction between epicardial and endocardia l layers in radial and cross-fiber segments, but not for fiber segments, de spite a gradient in blood flow reduction during ischemia. Perhaps systolic fiber dysfunction rather than the degree of perfusion deficit during the pr eceding ischemic period may be the main determinant of myocardial. dysfunct ion during reperfusion.