G. Vargas-alarcon et al., Immunogenetics and clinical aspects of Takayasu's arteritis patients in a Mexican Mestizo population, CLIN EXP RH, 19(4), 2001, pp. 439-443
Objective The aim of the present work was to study the association between
HLA alleles and Takayasu's arteritis in Mexican Mestizo patients.
Methods The study included 26 Mexican Mestizo patients with Takayasu's arte
ritis and 99 healthy unrelated individuals. HLA-A, -B and -DR alleles were
determined by polymerase chain reaction PCR-SSP
Results Increased gene frequencies were demonstrated for HLA-B15 (p=0.009,
pC=0.020, OR=3.24, EF=11.9%) and HLA-B52 (p=0.008, pC=0.027, OR=5.16, EF=7.
7%), and a decreased frequency for the HLA-A24 allele in patients compared
to normal controls (p=0.035, pC=NS, PF=11.1%). When HLA typing was correlat
ed to clinical features in 24 cases, we found an increased frequencies of H
LA-DR14 in patients with systemic arterial hypertension (p=0.005, pC=0.004,
OR=24.6 EF=38.3%) and HLA-A2 on patients with pulmonary involvement (p=0.0
34, pC=0.036, OR=3.67 EF=40.4%) when compared to patients without these cli
nical manifestations.
Conclusion These data confirm HLA-B52 as a relevant susceptibility allele f
or Takayasu's arteritis and suggest that HLA-B15 could be important as a ma
rker of the disease in Mexican patients. Other class I and/or class II alle
les could also be relevant as markers for the clinical features present in
these patients.