This study describes the clinical characteristics of tularemia in Spain's f
irst epidemic outbreak and the therapeutic response and compares the effica
cy of 3 antibiotics (streptomycin, ciprofloxacin, and doxycycline). For 142
cases of tularemia, the therapeutic failure rate was 22.5%; ciprofloxacin
was the antibiotic with the lowest percentage of therapeutic failures and w
ith the fewest side effects.