Stem cell fate and patterning in mammalian epidermis

Authors
Watt, FM
Citation
Fm. Watt, Stem cell fate and patterning in mammalian epidermis, CUR OP GEN, 11(4), 2001, pp. 410-417
Citations number
55
Categorie Soggetti
Cell & Developmental Biology
Journal title
CURRENT OPINION IN GENETICS & DEVELOPMENT
ISSN journal
0959437X → ACNP
Volume
11
Issue
4
Year of publication
2001
Pages
410 - 417
Database
ISI
SICI code
0959-437X(200108)11:4<410:SCFAPI>2.0.ZU;2-1
Abstract
Recent studies highlight characteristics of epidermal stem cells that were not fully appreciated before. Stem cells are multipotential and signals exc hanged with their neighbours help to regulate exit from the stem cell compa rtment and differentiation along specific lineages. Stem cells exhibit a hi gh degree of spatial organisation, and cell clustering and motility contrib ute to the assembly and maintenance of the epidermis.