Cell migration in invertebrates: clues from border and distal tip cells

Authors
Citation
R. Lehmann, Cell migration in invertebrates: clues from border and distal tip cells, CUR OP GEN, 11(4), 2001, pp. 457-463
Citations number
44
Categorie Soggetti
Cell & Developmental Biology
Journal title
CURRENT OPINION IN GENETICS & DEVELOPMENT
ISSN journal
0959437X → ACNP
Volume
11
Issue
4
Year of publication
2001
Pages
457 - 463
Database
ISI
SICI code
0959-437X(200108)11:4<457:CMIICF>2.0.ZU;2-0
Abstract
Recent studies in two invertebrate systems, border cells in Drosophila mela nogaster and distal tip cells in Caenorhabditis elegans, have provided impo rtant insight into the mechanisms of directed cell migration. These migrati ng cells are guided by extracellular signals, such as EGF, TGF-P and netrin . In addition, metalloproteases alter the extracellular matrix of the tissu e through which these cells migrate. Along the migratory path, migrating ce lls respond to changes in guidance signals by altering the expression of re ceptor signaling pathways. Finally, Dock180, CrklI and the GTPase Rac link the extracellular signals to the cellular machinery that controls cell moti lity.