M. Mock et al., Wegener's granulomatosis: Description of a case where cutaneous involvement was correlated with elevation of the c-ANCA titer, DERMATOLOGY, 202(4), 2001, pp. 347-349
Wegener's granulomatosis is a systemic disease characterized by necrotizing
granulomas and vasculitis involving the upper and lower respiratory tract
as well as the kidneys. Cutaneous manifestations consist mainly of papules
or papulonecrotic lesions. c-ANCA are known to be a valuable adjunct for th
e diagnosis and follow-up of Wegener's granulomatosis with systemic involve
ment. We report the case of a 49-year-old man with Wegener's granulomatosis
who developed two relapses of the disease with cutaneous manifestation and
who presented with concomitant elevation of the cANCA and more precisely t
he subset PR3-ANCA during the acute phase of the disease. Copyright (C) 200
1 S. Karger AG, Basel.