Cold agglutinin disease - The importance of cutaneous signs

We present the case of a woman where the diagnosis of cold agglutinin disea se could be made after we had noticed slight cutaneous manifestations durin g a routine examination. Leading symptoms were livedo reticularis of the th ighs and a history of acro-cyanosis and Raynaud's phenomenon upon cold expo sure. The current knowledge about the etiology, clinical presentation and t reatment of the disease is briefly discussed. Copyright (C) 2001 S.Karger A G, Basel.