Cholelithiasic disease and associated factors in a Spanish population

In order to analyze the factors associated with cholelithiasic disease, 126 8 participants of a population sample were studied. On univariate analysis, 11 of the 23 variables included showed a statistically significant associa tion (P < 0.05), Five of these variables, including obesity, triglyceride l evel, intake of hypolipidemic drugs, and a diet rich in cholesterol and sat urated fats in women, and physical exercise in men, remained significantly associated after controlling for age. On multivariate analysis among women, a positive association was found with age (P < 0.001), obesity, and the us e of hypolipidemic agents (P < 0.05) and a negative one with a diet rich in cholesterol and saturated fats (P < 0.05). Among men, the same analysis re vealed there was a positive association with age (P < 0.001) and triglyceri des (P < 0.05) and a negative one with physical exercise (P < 0.05). In con clusion, obesity and the use of hypolipidemic agents in women and triglycer ides in men, were positively associated with cholelithiasic disease, indepe ndent of age, while negative associations included the intake of cholestero l and saturated fats in women and physical exercise in men.