Acidic fibroblast growth factor is expressed sequentially in the progression from Barrett's esophagus to esophageal adenocarcinoma

Authors
Soslow, RA Petersen, CG Remotti, H Altorki, N
Citation
Ra. Soslow et al., Acidic fibroblast growth factor is expressed sequentially in the progression from Barrett's esophagus to esophageal adenocarcinoma, DIS ESOPHAG, 14(1), 2001, pp. 23-27
Citations number
26
Categorie Soggetti
Gastroenerology and Hepatology
Journal title
DISEASES OF THE ESOPHAGUS
ISSN journal
11208694 → ACNP
Volume
14
Issue
1
Year of publication
2001
Pages
23 - 27
Database
ISI
SICI code
1120-8694(2001)14:1<23:AFGFIE>2.0.ZU;2-K
Abstract
Acidic fibroblast growth factor 1 (FGF-1) is sequentially accumulated in Ba rrett's esophagus and its expression in glandular dysplasias is independent of esophageal adenocarcinoma. This suggests that FGF-1 immunohistochemistr y could be used as an adjunct to the routine histopathologic diagnosis of d ysplasia in Barrett's esophagus. The data also underscore the important rol e of fibroblast growth factors in tumorigenesis.