Subchronic administration of various pretreatments of nerve agent poisoning. I. Protection of blood and central cholinesterases, innocuousness towards blood-brain barrier permeability

PYR, a reversible AChE inhibitor, is the current pretreatment against OP in toxication. However, PHY in the presence or absence of SCO on one side. and HUP on the other side, could be considered as potential substitutes for PY R. In the present study, the effects of the subchronic administration of th ese different current or potential pretreatments on the BBB permeability fo r blood-borne albumin and on the activity of the blood and central cholines terases are comparatively evaluated in guinea-pigs. Altogether, although so me marginal disruptions of BBB are detected, the different current or poten tial pretreatments studied seem to have a total innocuousness on the permea bility of the BBB for proteins. Finally, at the light of its particular inh ibitory effects on blood and central cholinesterases, HUP, compared to the other drugs, seems to be the optimal candidate to be used as pretreatment a gainst OP poisoning.