Effect of chronic morphine administration on glucose tolerance and insulinbinding to isolated rat adipocytes

Authors
Sood, A Thakur, VS Karmarkar, MG Ahuja, MMS
Citation
A. Sood et al., Effect of chronic morphine administration on glucose tolerance and insulinbinding to isolated rat adipocytes, ENDOCRINE R, 27(1-2), 2001, pp. 215-221
Citations number
21
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
ENDOCRINE RESEARCH
ISSN journal
07435800 → ACNP
Volume
27
Issue
1-2
Year of publication
2001
Pages
215 - 221
Database
ISI
SICI code
0743-5800(2001)27:1-2<215:EOCMAO>2.0.ZU;2-U
Abstract
Morphine addiction was induced in six male Wistar rats. Improved glucose to lerance (peak value less by 28%, p < 0.01) was observed in chronically morp hinized rats as compared to the control rats, injected with saline. An incr ease in the maximal specific binding of I-125-labeled insulin to unit membr ane area of adipocytes was observed in the experimental group (p < 0.01). T he changes in insulin receptor number could be responsible for the improved glucose tolerance observed during morphine addiction.