Hypertonic-hyperoncotic solutions decrease cardiac troponin I concentrations in peripheral blood in a porcine ischemia-reperfusion model

In this study we addressed the question of whether the measurement of cardi ac Troponin I (cTnI) is able to reflect beneficial effects of hypertonic-hy peroncotic solutions after transient cardiac arrest. Ten pigs were anaesthe tized and cardiac arrest was induced by electric fibrillation. After 5 minu tes of global ischemia, cardiac arrest was reversed by electric defibrillat ion. Upon return of spontaneous circulation 5 animals received hypertonic-h yperoncotic solutions (10% Hydroxyethylstarch 200/0.5 and 7.2% NaCl). The o ther animals received equivalent volumes of physiological saline. We observ ed that cTnI serum levels of animals treated with hypertonic-hyperoncotic s olutions were significantly lower than those treated with saline. We conclu de that hypertonic-hyperoncotic solutions may have cardioprotective effects .