The methodology of clinical research will be commented upon according to th
e components of the research design: a precise question, hypotheses derived
from that which can be examined empirically, the biometrical estimation of
the sample size and its practicability, the selection of control groups, m
easures for assessing psychopathological phenomena, analysing the data and
preparing the findings for publication, further the time structure of the r
esearch project, and some aspects of the framework of clinical research: pa
tient access, financing of the needed resources and ethical implications.