As the human thumb climbed the evolutionary ladder, the trapeziometacarpal
joint was provided greater mobility at the expense of decreased bony stabil
ity. Soft tissue restraints were left to provide the primary stabilization
of the thumb basal joint complex. Both degenerative and traumatic condition
s compromise the function of these ligamentous structures and result in tra
nslational instability of the joint surfaces and secondary arthritic diseas
e. Primary idiopathic osteoarthritis, Bennett's fracture-dislocation, and m
etacarpophalangeal hypermobility all impart a disturbance in biomechanics w
hile extension metacarpal osteotomy, ligament reconstruction, and imposed m
etacarpophalangeal flexion mitigate these effects and improve trapeziometac
arpal kinematics. As a compact joint amenable to en bloc resection, the tra
peziometacarpal complex affords a Unique opportunity to study the inter-rel
ationship between biology and biomechanics in the pathogenesis of degenerat
ive joint disease.