Concurrent upregulation of urokinase plasminogen activator receptor and CD11b during tuberculosis and experimental endotoxemia

Authors
Juffermans, NP Dekkers, REP Verbon, A Speelman, P van Deventer, SJH van der Poll, T
Citation
Np. Juffermans et al., Concurrent upregulation of urokinase plasminogen activator receptor and CD11b during tuberculosis and experimental endotoxemia, INFEC IMMUN, 69(8), 2001, pp. 5182-5185
Citations number
16
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
69
Issue
8
Year of publication
2001
Pages
5182 - 5185
Database
ISI
SICI code
0019-9567(200108)69:8<5182:CUOUPA>2.0.ZU;2-M
Abstract
Patients with tuberculosis had higher expression of monocyte urokinase rece ptor (uPAR) and CD11b than controls. In vitro, lipoarabinomannan and lipopo lysaccharide (LPS) from Escherichia coli shared the ability to enhance uPAR and CD11b expression on monocytes and granulocytes. In healthy volunteers, LPS induced increases in monocyte and granulocyte uPAR and CD11b.