YLR209c encodes Saccharomyces cerevisiae purine nucleoside phosphorylase

Authors
Lecoq, K Belloc, I Desgranges, C Konrad, M Daignan-Fornier, B
Citation
K. Lecoq et al., YLR209c encodes Saccharomyces cerevisiae purine nucleoside phosphorylase, J BACT, 183(16), 2001, pp. 4910-4913
Citations number
20
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF BACTERIOLOGY
ISSN journal
00219193 → ACNP
Volume
183
Issue
16
Year of publication
2001
Pages
4910 - 4913
Database
ISI
SICI code
0021-9193(200108)183:16<4910:YESCPN>2.0.ZU;2-4
Abstract
The yeast YLR209c (PNP1) gene encodes a protein highly similar to purine nu cleoside phosphorylases. This protein specifically metabolized inosine and guanosine. Disruption of PNP1 led to inosine and guanosine excretion in the medium, thus showing that PNP1 plays an important role in the metabolism o f these purine nucleosides in vivo.