An athletic 8-year-old boy developed severe muscle weakness over 2 years. A
t the age of 10 years, investigation for possible neuromuscular disease dis
closed hypophosphatemia (1.8 mg/dl) and rickets. There was selective renal
tubular wasting of inorganic phosphate (Pi) but no history of toxin exposur
e, familial bone or kidney disease, or biochemical evidence of vitamin D de
ficiency. Urine amino acid quantitation was unremarkable. Serum 1,25-dihydr
oxyvitamin D [1,25(OH)(2)D] concentration was in the lower half of the refe
rence range. Our presumptive diagnosis was tumor-induced rickets; however,
physical examination and bone scanning in search of a neoplasm were unrevea
ling. Soon after 1,25(OH)(2)D-3 and Pi treatment began, muscle strength imp
roved considerably. After 6 months of therapy, radiographic abnormalities w
ere substantially better. During the next 6 years, physical examinations, a
second bone scan, whole-body and nasal sinus magnetic resonance imaging, a
nd octreotide scintigraphy were unremarkable. When his physes fused at the
age of 16 years, assessment of his course showed excellent control of his r
ickets requiring decreasing doses of medication. Furthermore, fasting serum
Pi levels and tubular maximum phosphorus/glomerular filtration (TmP/GFR) v
alues had increased steadily and normalized after 3 years of treatment. Acc
ordingly, therapy was stopped. Seven months after stopping medication, he c
ontinues to feel completely well. Fasting serum Pi levels, TmP/GFR, other b
iochemical parameters of bone and mineral homeostasis, creatinine clearance
, and renal sonography are normal. Neither spontaneous or pharmacologic cur
e of tumor-induced rickets or osteomalacia nor a patient matching ours has
been reported. His disorder, which we call pseudo-(tumor-induced) rickets,
should be considered when investigation for oncogenic rickets or osteomalac
ia discloses no causal lesion. Consequently, prolonged medical therapy and
futile searches for a neoplasm may be avoided.