QSAR for boiling points of "small" sulfides. Are the "high-quality structure-property-activity regressions" the real high quality QSAR models?

Our investigation was motivated by a recent paper concerning "high-quality structure-property-activity regressions" (J. Chem. Inf. Comput. Sci. 2000, 40, 899-905) for boiling points of small sulfides using variable connectivi ty indices. We performed QSAR study of the same data set using a logically preselected solvation index and obtained a very good one-parameter regressi on. The structures of the whole possible set of small sulfides (C2-C6) were generated and the statistics were proven by real prediction using an exter nal test set of sulfides. The variants of extended prediction with extrapol ated data and QSAR using an expanded training set were also performed, and all these data also revealed the preference of the solvation index. A gener al problem of descriptive vs predictive QSAR is discussed.