SEPARATION OF BASIC DRUG ENANTIOMERS BY CAPILLARY ELECTROPHORESIS WITH NEW GLYCOSAMINOGLYCAN

A new fucose-containing glycosaminoglycan was investigated as the chir al additive for the separation of basic drug enantiomers by capillary electrophoresis. Tolperisone and eperisone enantiomers were not separa ted with alpha- or beta-cyclodextrin, or heparin as the chiral additiv e, but were separated with the new fucose-containing glycosaminoglycan . A variety of basic drug enantiomers were resolved using 2-5%(w/w) so lution of the glycosaminoglycan in 10 mM phosphate buffer (final pH 5. 0).