N-PIVALOYL METHYL-ESTERS AS NOVEL DERIVATIVES OF AMINO-ACID ENANTIOMERS FOR CHIRAL-PHASE CAPILLARY GAS-CHROMATOGRAPHY

Amino acids were first acylated with pivaloyl chloride and then esteri fied with trimethylsilyldiazomethane in order to form volatile derivat ives for enantiomer separation by gas chromatography using capillary c olumn coated with chiral stationary phase. All the derivatives showed complete separation of their enantiomeric pair, especially in the case of Pro which is difficult to separate completely as in conventional N -perfluoroacyl alkyl ester derivatives.