M. Shibata et al., The presence of a newly identified infectious agent (SEN virus) in patients with liver diseases and in blood donors in Japan, J INFEC DIS, 184(4), 2001, pp. 400-404
The existence of the newly discovered SEN virus (SENV) was investigated in
379 Japanese patients with liver diseases and in 277 blood donors, to deter
mine whether SENV is associated with non-A-E hepatitis. SENV DNA was detect
ed by seminested polymerase chain reaction, with primers directed to 2 SENV
strains: SENV-H and SENV-D. SENV was detected in 7 (32%) of 22 patients wi
th fulminant hepatitis, in 15 (17%) of 86 patients with acute hepatitis, in
38 (27%) of 139 patients with chronic hepatitis, in 29 (31%) of 93 patient
s with liver cirrhosis, in 5 (33%) of 15 patients with autoimmune hepatitis
, in 11 (46%) of 24 patients with primary biliary cirrhosis, and in 27 bloo
d donors (10%). Infection occurred more frequently in patients with liver d
iseases than in blood donors; however, there were no significant difference
s in SENV-positive rates between patients with non-A-C hepatitis and those
with acute or chronic hepatitis due to known hepatitis virus or nonviral li
ver disease. This study did not suggest SENV as a possible causative agent
of non-A-C hepatitis.