Capillary zone electrophoresis analysis of anti-epileptic drugs

This paper describes the development of a simple, reliable, reproducible, a nd fast method, based on capillary zone electrophoresis with diode array de tection, for the separation and determination of two antiepileptic drugs. P henytoin (DPH) and phenobarbital (PB) were separated in 4 min by using a ca rrier containing glycine 50 mM, pH 10.5. The limit of detection was 0.1 ig mL(-1) for both compounds. Satisfactory reproducibility was obtained for mi gration times (<1.4%) and corrected peak areas (<6.9%) in the analysis of p harmaceutical formulations. The average recoveries obtained, which ranged b etween 100 and 108%, testify to the accuracy of the proposed method.