TOXIC EFFECT OF SODIUM DODECYLBENZENESULFONATE, LEAD, PETROLEUM, AND THEIR MIXTURES ON THE ACTIVITY OF ACETYLCHOLINESTERASE OF MOINA-MACROCOPA IN-VITRO

The inhibition of acetylcholinesterase activity (AChE) in Moina macroc opa homogenized with sodium dodecylbenzenesulfonate (DBSS), lead (Ph), crude oil (PO), and their mixtures was investigated. When the homogen ized cladoceran were exposed to these compounds in vitro, AChE activit y revealed that PO was the most potent anticholinesterase agent, follo wed by Mixture IV (DBSS-PO), Mixture I (DBSS), Mixture III (PO-DBSS), Ph, DBSS, and Mixture II (Pb-DBSS). All compounds and their mixtures c aused inhibition of M. macrocopa homogenized cholinesterase. This bioa ssay technique seems to have considerable potential as a rapid, sensit ive, and inexpensive procedure for hazard assessment and environmental evaluation. (C) 1997 by John Wiley & Sons, Inc.