Functional magnetic resonance imaging of working memory impairment after traumatic brain injury

Objectives-To examine patterns of brain activation while performing a worki ng memory task in persons with moderate to severe traumatic brain injury (T BI) and healthy controls. It is well established that working memory is an area of cognition that is especially vulnerable to disruption after TBI. Al though much has been learned about the system of cerebral representation of working memory in healthy people, little is known about how this system is disrupted by TBI. Methods-Functional magnetic resonance imaging (fMRI) was used to assess bra in activation during a working memory task (a modified version of the paced auditory serial addition test) in nine patients with TBI and seven healthy controls. Results-Patients with TBI were able to perform the task, but made significa ntly more errors than healthy controls. Cerebral activation in both groups was found in similar regions of the frontal, parietal, and temporal lobes, and resembled patterns of activation found in previous neuroimaging studies of working memory in healthy persons. However, compared with the healthy c ontrols, the TBI group displayed a pattern of cerebral activation that was more regionally dispersed and more lateralised to the right hemisphere. Dif ferences in lateralisation were particularly evident in the frontal lobes. Conclusions-Impairment of working memory in TBI seems to be associated with alterations in functional cerebral activity.