PYRAZINAMIDE-INDUCED GRANULOMATOUS HEPATITIS

Noncaseating granulomatous hepatitis may be caused by a variety of dru gs, but we have not found, by computer search of the literature, a pre vious describe of granulomatous hepatitis associated with pyrazinamide . We describe a 52-year-old man with hectic fever, chills, extreme fat igue, liver damage, and hyperuricemia about 4 weeks after commencing p yrazinamide therapy. A liver biopsy specimen showed noncaseating epith elioid granulomas. The patient recovered soon after the interruption o f tuberculostatic treatment.