Solid phase synthesis of sulphonamides: novel ligands of 5-MT6 receptors

Using solid phase synthesis techniques, we have rapidly obtained a series o f eight aryl sulphonamides derived from putrescine. These conjugates with v arious aryl groups were evaluated for their affinity towards 5-HT6 receptor s in man. This evaluation revealed the interest of two compounds which pres ent the same activity level, in the submicromolar range, as two reference d erivatives. The most potent will be considered as a new lead for further in vestigations.