ADENOSINE RECEPTOR AGENTS AND CONDITIONED PLACE PREFERENCE

1. The effects of different doses of the adenosine agonists N5-ethylca rboxamido-adenosine (NECA), R-isomer of N-6-phenylisopropdadenosine (R -PIA), and N-6-cyclohexyladenosine (CHA) or of the antagonists theophy lline and 8-phenyltheophylline (8-PT) on conditioned place preference (CPP) have been studied. 2. The results show that R-PTA and CHA induce d conditioned place aversion (CPA) whereas NECA induced conditioned pl ace preference (CPP). 3. Low doses of theophylline elicit CPP, but hig h doses of the drug induced CPA. 8-PT also produced the CPP. 4. The re sponses of R-PIA and CHA but not NECA was decreased by theophylline an d 8-PT administration. 5. It is concluded that the induction of CPP an d CPA by adenosine antagonsists may be mediated by different adenosine receptors. GEN PHARMAC 29;2:285-289, 1997. (C) 1997 Elsevier Science Inc.