Role for p53 in gene induction by double-stranded RNA

Authors
Hummer, BT Li, XL Hassel, BA
Citation
Bt. Hummer et al., Role for p53 in gene induction by double-stranded RNA, J VIROLOGY, 75(16), 2001, pp. 7774-7777
Citations number
42
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF VIROLOGY
ISSN journal
0022538X → ACNP
Volume
75
Issue
16
Year of publication
2001
Pages
7774 - 7777
Database
ISI
SICI code
0022-538X(200108)75:16<7774:RFPIGI>2.0.ZU;2-2
Abstract
Cross talk between p53 and interferon-regulated pathways is implicated in t he induction of gene expression by biologic and genotoxic stresses. We demo nstrate that the interferon-stimulated gene ISG15 is induced by p53 and tha t p53 is required for optimal gene induction by double-stranded RNA (dsRNA) , but not interferon. Interestingly, virus induces ISG15 in the absence of p53, suggesting that virus and dsRNA employ distinct signaling pathways.