Analysis of virus-specific CD4(+) T cells during long-term gammaherpesvirus infection

Authors
Flano, E Woodland, DL Blackman, MA Doherty, PC
Citation
E. Flano et al., Analysis of virus-specific CD4(+) T cells during long-term gammaherpesvirus infection, J VIROLOGY, 75(16), 2001, pp. 7744-7748
Citations number
40
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF VIROLOGY
ISSN journal
0022538X → ACNP
Volume
75
Issue
16
Year of publication
2001
Pages
7744 - 7748
Database
ISI
SICI code
0022-538X(200108)75:16<7744:AOVCTC>2.0.ZU;2-I
Abstract
Major histocompatibility complex class II-mediated antigen presentation aft er intranasal infection with murine gammaherpesvirus 68 differs in mediasti nal lymph nodes and spleen. Evidence that virus-specific CD4(+) T cells wer e being stimulated was found as late as 6 to 8 months after infection, and cells specific for the viral gp150(67-83) and ORF11(168-180) peptides were maintained as a fairly stable proportion of the total response.