NOSYLAZIRIDINES - ACTIVATED AZIRIDINE ELECTROPHILES

Authors
MALIGRES PE SEE MM ASKIN D REIDER PJ
Citation
Pe. Maligres et al., NOSYLAZIRIDINES - ACTIVATED AZIRIDINE ELECTROPHILES, Tetrahedron letters, 38(30), 1997, pp. 5253-5256
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
30
Year of publication
1997
Pages
5253 - 5256
Database
ISI
SICI code
0040-4039(1997)38:30<5253:N-AAE>2.0.ZU;2-J
Abstract
Nosylaziridines are highly reactive electrophiles towards a variety of nucleophiles yielding the corresponding SN2 adducts without competing attack on the nosyl functionality (SNAr). The resulting primary nosyl amide adducts can be readily cleaved under mild conditions to provide the primary amines. (C) 1997 Elsevier Science Ltd.