Syntheses of two deacetyl-thymosin beta(4) analogs and their anti-inflammatory effect on carrageenin-induced edema in the mouse paw

Authors
Abiko, T Ogawa, R
Citation
T. Abiko et R. Ogawa, Syntheses of two deacetyl-thymosin beta(4) analogs and their anti-inflammatory effect on carrageenin-induced edema in the mouse paw, MEDIAT INFL, 10(2), 2001, pp. 89-92
Citations number
5
Categorie Soggetti
Immunology
Journal title
MEDIATORS OF INFLAMMATION
ISSN journal
09629351 → ACNP
Volume
10
Issue
2
Year of publication
2001
Pages
89 - 92
Database
ISI
SICI code
0962-9351(2001)10:2<89:SOTDBA>2.0.ZU;2-B
Abstract
Two {Met(0)(6)}deacetyl-thymosin beta (4) analogs containing Phe(4F) or Tyr (Me) at position 12 were synthesized by the manual solid-phase method, and their anti-inflammatory effect on carrageenin-induced edema in the mouse pa w was studied. Fluorination of the para-position of Phe 12 resulted in a ma rked antiinflammatory effect on carrageenin-induced edema in the mouse paw compared with that of our synthetic {Met(0)(6)}deacetyl-thymosin beta (4), but the other analog, {Met(0)(6), Tyr(Me)(12)}deacetyl-thymosin beta (4), s howed a marked reduction of the anti-inflammatory effect.